Recent Research

 

 Publications

  1. HIV persists in late coronary atheroma and is associated with increased local inflammation and disease progression. Obare LM, Bailin SS, Zhang X, Nthenge K … Bick AG et al. Res Sq. 2024 Oct 18:rs.3.rs-5125826. doi: https://doi.org/10.21203/rs.3.rs-5125826/v1.

  2. Salt and CHIP: Tet2-CH Aggravates Salt-Sensitive Hypertension in Mice. Vlasschaert C, Crowley SD, Bick AG. Circ Res. 2024 Oct 11;135(9):951-953. doi: https://doi.org/10.1161/CIRCRESAHA.124.325364. Epub 2024 Oct 10.

  3. CHIP shot: aiming at therapy-induced clonal hematopoiesis. Luo LY, Bick AG. Blood Adv. 2024 Oct 8;8(19):5213-5214. doi: https://doi.org/10.1182/bloodadvances.2024013724.

  4. Variance quantitative trait loci reveal gene-gene interactions which alter blood traits. Pershad Y, Poisner H, Corty RW, Hellwege JN, Bick AG. medRxiv. 2024 Sep 19:2024.09.18.24313883. doi: https://doi.org/10.1101/2024.09.18.24313883.

  5. Cost-effective solutions for high-throughput enzymatic DNA methylation sequencing. Longtin A, Watowich MM, Sadoughi B, Petersen RM … Bick AG, Lea AJ. bioRxiv. 2024 Sep 9:2024.09.09.612068. doi: https://doi.org/10.1101/2024.09.09.612068.

  6. Subset-specific mitochondrial stress and DNA damage shape T cell responses to fever and inflammation. Heintzman DR, Sinard RC, Fisher EL, Ye X … Bick AG, Rathmell WK, Wilson JT, Rathmell JC. Sci Immunol. 2024 Sep 20;9(99):eadp3475. doi: https://doi.org/10.1126/sciimmunol.adp3475. Epub 2024 Sep 20.

  7. Myeloid-Specific JAK2 Contributes to Inflammation and Salt Sensitivity of Blood Pressure. Saleem M, Aden LA, Mutchler AL, Basu C … Bick AG, Kleyman TR, Kirabo A. Circ Res. 2024 Oct 11;135(9):890-909. doi: https://doi.org/10.1161/CIRCRESAHA.124.323595. Epub 2024 Sep 12.

  8. Long-term longitudinal analysis of 4,187 participants reveals insights into determinants of clonal hematopoiesis. Uddin MM, Saadatagah S, Niroula A, Yu B … Bick AG, et al. Nat Commun. 2024 Sep 9;15(1):7858. doi: https://doi.org/10.1038/s41467-024-52302-9.

  9. The Genetic Determinants and Genomic Consequences of Non-Leukemogenic Somatic Point Mutations. Weinstock JS, Chaudhry SA, Ioannou M, Viskadourou M … Bick A, Post WS, Scheet P, Auer P, Karantanos T, Battle A, Arvanitis M. medRxiv. 2024 Aug 26:2024.08.22.24312319. doi: https://doi.org/10.1101/2024.08.22.24312319.

  10. PheMIME: an interactive web app and knowledge base for phenome-wide, multi-institutional multimorbidity analysis. Zhang S, Strayer N, Vessels T, Choi K, Wang GW, Li Y, Bejan CA, Hsi RS, Bick AG, et al. J Am Med Inform Assoc. 2024 Nov 1;31(11):2440-2446. doi: https://doi.org/10.1093/jamia/ocae182.

  11. Genetic determinants and phenotypic consequences of blood T-cell proportions in 207,000 diverse individuals. Poisner H, Faucon A, Cox N, Bick AG. Nat Commun. 2024 Aug 7;15(1):6732. doi: https://doi.org/10.1038/s41467-024-51095-1.

  12. Clonal hematopoiesis, cardiovascular events and treatment benefit in 63,700 individuals from five TIMI randomized trials. Marston NA, Pirruccello JP, Melloni GEM, Kamanu F … Bick AG, Sabatine MS, Ruff CT. Nat Med. 2024 Sep;30(9):2641-2647. doi: https://doi.org/10.1038/s41591-024-03188-z. Epub 2024 Aug 6.

  13. JAK2-mutant clonal hematopoiesis is associated with venous thromboembolism. Zon RL, Sekar A, Clapham K, Oren O, Niroula A, Bick AG, et al. Blood. 2024 Nov 14;144(20):2149-2154. doi: https://doi.org/10.1182/blood.2024024187.

  14. Epigenome-wide DNA Methylation Association Study of CHIP Provides Insight into Perturbed Gene Regulation. Levy D, Kirmani S, Huan T, Van Amburg J … Bick A. Res Sq. 2024 Jul 16:rs.3.rs-4656898. doi: https://doi.org/10.21203/rs.3.rs-4656898/v1.

  15. Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Verma A, Huffman JE, Rodriguez A, Conery M … Bick AG, et al. Science. 2024 Jul 19;385(6706):eadj1182. doi: https://doi.org/10.1126/science.adj1182. Epub 2024 Jul 19.

  16. Association of clonal hematopoiesis and mosaic chromosomal alterations with solid malignancy incidence and mortality. Desai P, Zhou Y, Grenet J, Handelman SK … Bick A, et al. Cancer. 2024 Nov 15;130(22):3879-3887. doi: https://doi.org/10.1002/cncr.35455. Epub 2024 Jul 16.

  17. Clonal hematopoiesis of indeterminate potential contributes to accelerated chronic kidney disease progression. Vlasschaert C, Pan Y, Chen J, Akwo E … Bick AG, et al. medRxiv. 2024 Jun 20:2024.06.19.24309181. doi: https://doi.org/10.1101/2024.06.19.24309181.

  18. Invasive Assessment of Coronary Artery Disease in Clonal Hematopoiesis of Indeterminate Potential. Heimlich JB, Raddatz MA, Wells J, Vlasschaert C … Bick AG. Circ Genom Precis Med. 2024 Aug;17(4):e004415. doi: https://doi.org/10.1161/CIRCGEN.123.004415. Epub 2024 Jun 28.

  19. Adaptive selection at G6PD and disparities in diabetes complications. Breeyear JH, Hellwege JN, Schroeder PH, House JS, Poisner HM … Bick AG, et al. Nat Med. 2024 Sep;30(9):2480-2488. doi: https://doi.org/10.1038/s41591-024-03089-1. Epub 2024 Jun 25.

  20. Genetic drivers and cellular selection of female mosaic X chromosome loss. Liu A, Genovese G, Zhao Y, Pirinen M … Bick A, et al. Nature. 2024 Jul;631(8019):134-141. doi: https://doi.org/10.1038/s41586-024-07533-7. Epub 2024 Jun 12.

  21. Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate. Mack TM, Raddatz MA, Pershad Y, Nachun DC … Bick AG. Nat Aging. 2024 Aug;4(8):1043-1052. doi: https://doi.org/10.1038/s43587-024-00647-7. Epub 2024 Jun 4.

  22. Determinants of mosaic chromosomal alteration fitness. Pershad Y, Mack T, Poisner H, Jakubek YA … Bick AG. Nat Commun. 2024 May 7;15(1):3800. doi: https://doi.org/10.1038/s41467-024-48190-8.

  23. Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood. Jakubek YA, Ma X, Stilp AM, Yu F … Bick AG, Sankaran VG, Reiner AP, Scheet P, Auer PL. medRxiv. 2024 Apr 19:2024.04.16.24305851. doi: https://doi.org/10.1101/2024.04.16.24305851.

  24. Clonal hematopoiesis and inflammation in the vasculature: CHIVE, a prospective, longitudinal clonal hematopoiesis cohort and biorepository. Shannon ML, Heimlich JB, Olson S, Debevec A … Bick AG, Savona MR. Blood Adv. 2024 Jul 9;8(13):3453-3463. doi: https://doi.org/10.1001/10.1182/bloodadvances.2023011510.

  25. Atrial Fibrillation and Clonal Hematopoiesis in TET2 and ASXL1. Saadatagah S, Naderian M, Uddin M, Dikilitas O … Bick AG, et al. JAMA Cardiol. 2024 Jun 1;9(6):497-506. doi: https://doi.org/10.1001/jamacardio.2024.0459.

  26. Cost-Effective and Scalable Clonal Hematopoiesis Assay Provides Insight into Clonal Dynamics. Mack T, Vlasschaert C, von Beck K, Silver AJ, Heimlich JB, Poisner H, Condon HR, Ulloa J, Sochacki AL, Spaulding TP, Kishtagari A, Bejan CA, Xu Y, Savona MR, Jones A, Bick AG. J Mol Diagn. 2024 Jul;26(7):563-573. doi: https://doi.org/10.1016/j.jmoldx.2024.03.007. Epub 2024 Apr 6.

  27. Interoperability of phenome-wide multimorbidity patterns: a comparative study of two large-scale EHR systems. Strayer N, Vessels T, Choi K, Zhang S, Li Y, Han L, Sharber B, Hsi RS, Bejan CA, Bick AG et al. medRxiv. 2024 May 27:2024.03.28.24305045. doi: https://doi.org/10.1101/2024.03.28.24305045.

  28. Neutrophil-mediated innate immune resistance to bacterial pneumonia is dependent on Tet2 function. Quin C, DeJong EN, Cook EK, Luo YZ … Bick AG, Archer SL, Rauh MJ, Bowdish DM. J Clin Invest. 2024 Apr 4;134(11):e171002. doi: https://doi.org/10.1172/JCI171002.

  29. Solid Organ Transplant Recipients Exhibit More TET2-Mutant Clonal Hematopoiesis of Indeterminate Potential Not Driven by Increased Transplantation Risk. Silver AJ, Vlasschaert C, Mack T, Sharber B, Xu Y, Bick AG, Pinson CW, Savona MR. Clin Cancer Res. 2024 Jun 3;30(11):2475-2485. doi: https://doi.org/10.1158/1078-0432.CCR-23-3840.

  30. Multiomic profiling of human clonal hematopoiesis reveals genotype and cell-specific inflammatory pathway activation. Heimlich JB, Bhat P, Parker AC, Jenkins MT … Bick AG, Ferrell PB. Blood Adv. 2024 Jul 23;8(14):3665-3678. doi: https://doi.org/10.1182/bloodadvances.2023011445.

  31. Clonal hematopoiesis of indeterminate potential is associated with acute kidney injury. Vlasschaert C, Robinson-Cohen C, Chen J, Akwo E … Bick AG. Nat Med. 2024 Mar;30(3):810-817. doi: https://doi.org/10.1038/s41591-024-02854-6. Epub 2024 Mar 7.

  32. Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation. Lin AE, Bapat AC, Xiao L, Niroula A … Bick AG, et al. Circulation. 2024 Apr 30;149(18):1419-1434. doi: https://doi.org/10.1101/10.1161/CIRCULATIONAHA.123.065597. Epub 2024 Feb 15.

  33. Clonal hematopoiesis of indeterminate potential-associated non-small cell lung cancer risk is potentiated by small particulate matter air pollution among non-smokers: a novel somatic variant-environment interaction. Vlasschaert C, Buttigieg M, Pershad Y, Lanktree M, Aldrich MC, Rauh MJ, Bick AG. medRxiv. 2024 Jan 17:2024.01.17.24301439. doi: https://doi.org/10.1101/2024.01.17.24301439.

  34. Clonal Hematopoiesis and Incident Heart Failure With Preserved Ejection Fraction. Schuermans A, Honigberg MC, Raffield LM, Yu B, Roberts MB, … Bick AG, et al. JAMA Netw Open. 2024 Jan 2;7(1):e2353244. doi: https://doi.org/10.1001/jamanetworkopen.2023.53244.

  35. Germline and Somatic Mutations in DNA Methyltransferase 3A (DNMT3A) Predispose to Pulmonary Arterial Hypertension (PAH) in Humans and Mice: Implications for Associated PAH. Al-Qazazi R, Emon IM, Potus F, Martin AY, Lima PDA … Bick AG, et al. medRxiv. 2023 Dec 31:2023.12.30.23300391. doi: https://doi.org/10.1101/2023.12.30.23300391.

  36. Clonal Hematopoiesis Risk Score and All-Cause and Cardiovascular Mortality in Older Adults. Saadatagah S, Uddin MM, Weeks LD, Niroula A, Ru M, Takahashi K, Gondek L, Yu B, Bick AG, et al. JAMA Netw Open. 2024 Jan 2;7(1):e2351927. doi: https://doi.org/10.1001/jamanetworkopen.2023.51927.

  37. Driver mutation zygosity is a critical factor in predicting clonal hematopoiesis transformation risk. Kishtagari A, Khan MAW, Li Y, Vlasschaert C … Bick AG. Blood Cancer J. 2024 Jan 15;14(1):6. doi: https://doi.org/10.1038/s41408-023-00974-9.

  38. VEXAS-Defining UBA1 Somatic Variants in 245,368 Diverse Individuals in the NIH All Of Us Cohort. Corty RW, Brogan J, Byram K, Springer J, Grayson PC, Bick AG. Arthritis Rheumatol. 2024 Jun;76(6):942-948. doi: https://doi.org/10.1002/art.42802. Epub 2024 Feb 29.

  39. Radon Exposure, Clonal Hematopoiesis, and Stroke Susceptibility in the Women's Health Initiative. Anthony KM, Collins JM, Love SM, Stewart JD … Bick AG et al. Neurology. 2024 Jan 23;102(2):e208055. doi: https://doi.org/10.1212/WNL.0000000000208055. Epub 2024 Jan 3.

  40. Individual and Neighborhood-level Socioeconomic Status and Somatic Mutations Associated With Increased Risk of Cardiovascular Disease and Mortality: A Cross-Sectional Analysis in the Women's Health Initiative. Love SM, Collins JM, Anthony KM, Buchheit SF … Bick AG, et al. Women’s Health Issues. 2024 Mar-Apr;34(2):197-207. doi: https://doi.org/10.1016/j.whi.2023.10.005. Epub 2023 Dec 6.

  41. Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias. Schuermans A, Vlasschaert C, Nauffal V, Cho SMJ … Bick AG, Ellinor PT, Natarajan P, Honigberg MC. Eur Heart J. 2024 Mar 7;45(10):791-805. doi: https://doi.org/10.1093/eurheartj/ehad670.

  42. Mosaic chromosomal alterations in blood across ancestries using whole-genome sequencing. Jakubek YA, Zhou Y, Stilp A, Bacon J … Bick AG, Reiner AP, Scheet P, Auer PL. Nat Genet. 2023 Nov;55(11):1912-1919. doi: https://doi.org/10.1038/s41588-023-01553-1. Epub 2023 Oct 30.

  43. SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation. Chen CW, Zhang L, Dutta R, Niroula A, Miller PG, Gibson CJ, Bick AG, et al. Cell Stem Cell. 2023 Nov 2;30(11):1503-1519.e8. doi: https://doi.org/10.1016/j.stem.2023.09.011. Epub 2023 Oct 19.

  44. Genetic Inhibition of APOL1 Pore-Forming Function Prevents APOL1-Mediated Kidney Disease. Hung AM, Assimon VA, Chen HC, Yu Z … Bick AG, Million Veteran Program. J Am Soc Nephrol. 2023 Nov 1;34(11):1889-1899. doi: https://doi.org/10.1681/ASN.0000000000000219. Epub 2023 Oct 6.

  45. Clonal Somatic Mutations in Chronic Lung Diseases Are Associated with Reduced Lung Function. Yun JH, Khan MAW, Ghosh A, Hobbs BD … Bick AG. Am J Respir Crit Care Med. 2023 Dec 1;208(11):1196-1205. doi: https://doi.org/10.1164/rccm.202303-0395OC.

  46. Clonal Hematopoiesis of Indeterminate Potential (CHIP) and Incident Type 2 Diabetes Risk. Tobias DK, Manning AK, Wessel J, Raghavan S, Westerman KE, Bick AG, et al. Diabetes Care. 2023 Nov 1;46(11):1978-1985. doi: https://doi.org/10.2337/dc23-0805.

  47. Infection risk associated with clonal hematopoiesis of indeterminate potential is partly mediated by hematologic cancer transformation in the UK Biobank. Vlasschaert C, Akwo E, Robinson-Cohen C, Cook EK, Lanktree MB, Rauh MJ, Bick AG. Leukemia. 2023 Nov;37(11):2306-2308. doi: https://doi.org/10.1038/s41375-023-02023-7. Epub 2023 Sep 9.

  48. Demonstrating paths for unlocking the value of cloud genomics through cross cohort analysis. Deflaux N, Selvaraj MS, Condon HR, Mayo K … Bick AG. Nat Commun. 2023 Sep 5;14(1):5419. doi: https://doi.org/10.1038/s41467-023-41185-x.

  49. Blockade of IL-6 signaling alleviates atherosclerosis in Tet2-deficient clonal hematopoiesis. Liu W, Yalcinkaya M, Maestre IF, Olszewska M … Bick AG, et al. Nat Cardiovasc Res. 2023 Jun;2(6):572-586. doi: https://doi.org/10.1038/s44161-023-00281-3. Epub 2023 Jun 8.

  50. Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk. Yu Z, Fidler TP, Ruan Y, Vlasschaert C … Bick AG, Tall AR, Natarajan P. J Clin Invest. 2023 Sep 15;133(18):e168597. doi: https://doi.org/10.1172/JCI168597.

  51. Age at Menopause, Leukocyte Telomere Length, and Coronary Artery Disease in Postmenopausal Women. Schuermans A, Nakao T, Uddin MM, Hornsby W … Bick AG, Manson JE, Natarajan P, Honigberg MC. Circ Res. 2023 Aug 18;133(5):376-386. doi: https://doi.org/10.1161/CIRCRESAHA.123.322984. Epub 2023 Jul 25.

  52. Prediction of risk for myeloid malignancy in clonal hematopoiesis. Weeks LD, Niroula A, Neuberg D, Wong W, Lindsley RC … Bick AG, Malcovati L, Natarajan P, Ebert BL. NEJM Evid. 2023 May;2(5):10.1056/evidoa2200310. doi: https://doi.org/10.1056/evidoa2200310. Epub 2023 Apr 25.

  53. Associations between Ambient Air Pollutants and Clonal Hematopoiesis of Indeterminate Potential. Leiser CL, Whitsel EA, Reiner A, Rich SS, Rotter JI ...Bick AG, Szpiro AA, Kaufman JD. Cancer Epidemiol Biomarkers Prev. 2023 Oct 2;32(10):1470-1473. doi: https://doi.org/10.1158/1055-9965.EPI-23-0305.

  54. Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood. Schuermans A, Nakao T, Ruan Y, Koyama S … Bick AG, Niroula A, Jaiswal S, Ebert BL, Natarajan P, Honigberg MC. J Am Heart Assoc. 2023 Jul 4;12(13):e030220. doi: https://doi.org/10.1161/JAHA.123.030220. Epub 2023 Jun 22.

  55. Association of Clonal Hematopoiesis of Indeterminate Potential with Incident Heart Failure with Preserved Ejection Fraction. Reiner AP, Roberts MB, Honigberg MC, Kooperberg C, Desai P, Bick AG, Natarajan P, Manson JE, Whitsel EA, Eaton CB. medRxiv. 2023 Jun 10:2023.06.07.23291038. doi: https://doi.org/10.1101/2023.06.07.23291038.

  56. Clonal hematopoiesis is associated with protection from Alzheimer's disease. Bouzid H, Belk JA, Jan M, Qi Y … Bick AG, et al. Nat Med. 2023 Jul;29(7):1662-1670. doi: https://doi.org/10.1038/s41591-023-02397-2. Epub 2023 Jun 15.

  57. Genome-Wide Association Study of CKD Progression. Robinson-Cohen C, Triozzi JL, Rowan B, He J … Bick A, et al. J Am Soc Nephrol. 2023 Sep 1;34(9):1547-1559. doi: https://doi.org/10.1681/ASN.0000000000000170. Epub 2023 Jun 1.

  58. Increased Risk of Thoracic Aortic Aneurysms With JAK2 V617F. Nakao T, Yu Z, Vlasschaert C, Uddin MM, Lindsay ME, Ellinor PT, Ebert BL, Bick AG, Pirruccello JP, Natarajan P. J Am Coll Cardiol. 2023 May 30;81(21):2128-2130. doi: https://doi.org/10.1016/j.jacc.2023.03.413.

  59. Clonal Hematopoiesis of Indeterminate Potential Predicts Adverse Outcomes in Patients With Atherosclerotic Cardiovascular Disease. Gumuser ED, Schuermans A, Cho SMJ, Sporn ZA, Uddin MM … Bick AG, Natarajan P, Honigberg MC. J Am Coll Cardiol. 2023 May 23;81(20):1996-2009. doi: https://doi.org/10.1016/j.jacc.2023.03.401.

  60. Clonal hematopoiesis of indeterminate potential and outcomes after heart transplantation: A multicenter study. Amancherla K, Schlendorf KH, Vlasschaert C, Lowery BD … Bick AG, Clerkin K. Am J Transplant. 2023 Aug;23(8):1256-1263. doi: https://doi.org/10.1016/j.ajt.2023.04.028. Epub 2023 May 6.

  61. The genetic determinants of recurrent somatic mutations in 43,693 blood genomes. Weinstock JS, Laurie CA, Broome JG, Taylor KD … Bick AG, et al. Sci Adv. 2023 Apr 28;9(17):eabm4945. doi: https://doi.org/10.1126/sciadv.abm4945. Epub 2023 Apr 26.

  62. Clonal Hematopoiesis in Young Women Treated for Breast Cancer. Gibson CJ, Fell G, Sella T, Sperling AS, Snow C, Rosenberg SM, Kirkner G, Patel A, Dillon D, Bick AG, et al. Clin Cancer Res. 2023 Jul 5;29(13):2551-2558. doi: https://doi.org/10.1158/1078-0432.CCR-23-0050.

  63. Obesity-induced inflammation exacerbates clonal hematopoiesis. Pasupuleti SK, Ramdas B, Burns SS, Palam LR, Kanumuri R … Bick AG, et al. J Clin Invest. 2023 Jun 1;133(11):e163968. doi: https://doi.org/10.1172/JCI163968.

  64. Clonal haematopoiesis and risk of chronic liver disease. Wong WJ, Emdin C, Bick AG, Zekavat SM, Niroula A, et al. Nature. 2023 Apr;616(7958):747-754. doi: https://doi.org/10.1038/s41586-023-05857-4. Epub 2023 Apr 12.

  65. Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis. Weinstock JS, Gopakumar J, Burugula BB, Uddin MM, Jahn N, Belk JA, Bouzid H, Daniel B, Miao Z, Ly N, Mack TM … Bick AG, Jaiswal S. Nature. 2023 Apr;616(7958):755-763. doi: https://doi.org/10.1038/s41586-023-05806-1. Epub 2023 Apr 12.

  66. TP53-mediated clonal hematopoiesis confers increased risk for incident atherosclerotic disease. Zekavat SM, Viana-Huete V, Matesanz N, Jorshery SD … Bick AG, Fuster JJ, Klarin D.  Nat Cardiovasc Res. 2023 Jan 16;2:144-158. doi: https://doi.org/10.1038/s44161-022-00206-6.

  67. Genetic Determinants of IL-6 Levels and Risk of ESKD. Wheless L, Pike MM, Chen HC, Yu Z, Tao R, Bick A, Chung CP, Robinson-Cohen C, Hung A. Kidney360. 2023 Feb 1;4(2):241-244. doi: https://doi.org/10.34067/KID.0003332022. Epub 2022 Dec 14.

  68. Population analyses of mosaic X chromosome loss identify genetic drivers and widespread signatures of cellular selection. Liu A, Genovese G, Zhao Y, Pirinen M … Bick A, et al. medRxiv. 2023 Jan 31:2023.01.28.23285140. doi: https://doi.org/10.1101/2023.01.28.23285140.

  69. Interleukin-6 Receptor Polymorphism Attenuates Clonal Hematopoiesis-Mediated Coronary Artery Disease Risk Among 451 180 Individuals in the UK Biobank. Vlasschaert C, Heimlich JB, Rauh MJ, Natarajan P, Bick AG. Circulation. 2023 Jan 24;147(4):358-360. doi: https://doi.org/10.1161/CIRCULATIONAHA.122.062126. Epub 2023 Jan 23.

  70. A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets. Vlasschaert C, Mack T, Heimlich JB, Niroula A, Uddin MM … Bick AG. Blood. 2023 May 4;141(18):2214-2223. doi: https://doi.org/10.1182/blood.2022018825.

  71. Lymphoid clonal hematopoiesis: implications for malignancy, immunity, and treatment. von Beck K, von Beck T, Ferrell PB Jr, Bick AG, Kishtagari A. Blood Cancer J. 2023 Jan 4;13(1):5. doi: https://doi.org/10.1038/s41408-022-00773-8.

  72. Genetics of varicose veins reveals polygenic architecture and genetic overlap with arterial and venous disease. Levin MG, Huffman JE, Verma A, Sullivan KA … Bick AG, et al. Nat Cardiovasc Res. 2023 Jan;2(1):44-57. doi: https://doi.org/10.1038/s44161-022-00196-5. Epub 2023 Jan 9.

  73. Genetic causes and cardiovascular consequences of clonal hematopoiesis in the UK Biobank. Beeler JS, Bick AG, Bolton KL. Nat Cardiovasc Res. 2023 Jan;2(1):13-15. doi: https://doi.org/10.1038/s44161-022-00198-3.

  74. Clonal Hematopoiesis of Indeterminate Potential and Kidney Function Decline in the General Population. Kestenbaum B, Bick AG, Vlasschaert C, Rauh MJ, et al. Am J Kidney Dis. 2023 Mar;81(3):329-335. doi: 10.1053/j.ajkd.2022.08.014. Epub 2022 Oct 11.

  75. Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease. Uddin MDM, Nguyen NQH, Yu B, Brody JA … Bick AG, et al. Nat Commun. 2022 Sep 12;13(1):5350. doi: https://doi.org/10.1038/s41467-022-33093-3.

  76. Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals. Tahir UA, Katz DH, Avila-Pachecho J, Bick AG, et al. Nat Commun. 2022 Aug 22;13(1):4923. doi: https://doi.org/10.1038/s41467-022-32275-3.

  77. Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods. Katz DH, Robbins JM, Deng S, Tahir UA, Bick AG, et al. Sci Adv. 2022 Aug 19;8(33):eabm5164. doi: https://doi.org/10.1126/sciadv.abm5164. Epub 2022 Aug 19.

  78. Large-scale genome-wide association study of coronary artery disease in genetically diverse populations. Tcheandjieu C, Zhu X, Hilliard AT, Clarke SL … Bick AG, et al. Nat Med. 2022 Aug;28(8):1679-1692. doi: https://doi.org/10.1038/s41591-022-01891-3. Epub 2022 Aug 1.

  79. Clonal Hematopoiesis Analyses in Clinical, Epidemiologic, and Genetic Aging Studies to Unravel Underlying Mechanisms of Age-Related Dysfunction in Humans. Walsh K, Raghavachari N, Kerr C, Bick AG, et al. Front Aging. 2022 Mar 8;3:841796. doi: https://doi.org/10.3389/fragi.2022.841796.

  80. TET2-mutant clonal hematopoiesis and risk of gout. Agrawal M, Niroula A, Cunin P, McConkey M, Shkolnik V, Kim PG, Wong WJ, Weeks LD, Lin AE, Miller PG, Gibson CJ, Sekar A, Schaefer IM, Neuberg D, Stone RM, Bick AG, et al. Blood. 2022 Sep 8;140(10):1094-1103. doi: https://doi.org/10.1182/blood.2022015384.

  81. Modeling the temporal dynamics of clonal hematopoiesis. Jaiswal S, Bick AG. Nat Cardiovasc Res. 2022 Jun;1(6):537-538. doi: https://doi.org/10.1038/s44161-022-00086-w.

  82. Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics. Uddin MM, Zhou Y, Bick AG, et al. Immun Ageing. 2022 May 24;19(1):23. doi: https://doi.org/10.1186/s12979-022-00278-9.

  83. Genetics of smoking and risk of clonal hematopoiesis. Levin MG, Nakao T, Zekavat SM, Koyama S, Bick AG, Niroula A, Ebert B, Damrauer SM, Natarajan P. Sci Rep. 2022 May 4;12(1):7248. doi: https://doi.org/10.1038/s41598-022-09604-z.

  84. A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program. Verma A, Tsao NL, Thomann LO, Ho YL, Iyengar SK, Luoh SW, Carr R, Crawford DC, Efird JT, Huffman JE, Hung A, Ivey KL, Levin MG, Lynch J, Natarajan P, Pyarajan S, Bick AG et al. PLoS Genet. 2022 Apr 28;18(4):e1010113. doi: https://doi.org/10.1371/journal.pgen.1010113.

  85. Next Generation Risk Markers in Preventive Cardio-oncology. Lamberg M, Rossman A, Bennett A, Painter S, Goodman R, MacLeod J, Maddula R, Rayan D, Doshi K, Bick A, Bailey S, Brown SA. Curr Atheroscler Rep. 2022 Jun;24(6):443-456. doi: https://doi.org/10.1007/s11883-022-01021-x. Epub 2022 Apr 19.

  86. Patient-specific comorbidities as prognostic variables for survival in myelofibrosis. Sochacki AL, Bejan CA, Zhao S, Patel A … Bick AG, et al. Blood Adv. 2023 Mar 14;7(5):756-767. doi: https://doi.org/10.1182/bloodadvances.2021006318.

  87. Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential. Nakao T, Bick AG, Taub MA, Zekavat SM, Uddin MM, et al. Sci Adv. 2022 Apr 8;8(14):eabl6579. doi: https://doi.org/10.1126/sciadv.abl6579. Epub 2022 Apr 6.

  88. Clonal hematopoiesis and vascular disease. Amancherla K, Wells JA 4th, Bick AG. Semin Immunopathol. 2022 May;44(3):303-308. doi: https://doi.org/10.1007/s00281-022-00913-z. Epub 2022 Feb 4.

  89. APOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program. Hung AM, Shah SC, Bick AG, et al. JAMA Intern Med. 2022 Apr 1;182(4):386-395. doi: https://doi.org/10.1001/jamainternmed.2021.8538.

  90. Increased prevalence of clonal hematopoiesis of indeterminate potential amongst people living with HIV. Bick AG, Popadin K, Thorball CW, Uddin MM, et al. Sci Rep. 2022 Jan 12;12(1):577. doi: https://doi.org/10.1038/s41598-021-04308-2.

  91. Somatic Mutations in Cardiovascular Disease. Heimlich JB, Bick AG. Circ Res. 2022 Jan 7;130(1):149-161. doi: https://doi.org/10.1161/CIRCRESAHA.121.319809. Epub 2022 Jan 7.

  92. Clonal hematopoiesis in sickle cell disease. Liggett LA, Cato LD, Weinstock JS, Zhang Y … Bick AG, Sankaran VG. J Clin Invest. 2022 Feb 15;132(4):e156060. doi: https://doi.org/10.1172/JCI156060.

  93. Association of clonal hematopoiesis with chronic obstructive pulmonary disease. Miller PG, Qiao D, Rojas-Quintero J, Honigberg MC, Sperling AS, Gibson CJ, Bick AG, et al. Blood. 2022 Jan 20;139(3):357-368. doi: https://doi.org/10.1182/blood.2021013531.

  94. Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency. Dou H, Kotini A, Liu W, Fidler T … Bick A, et al. Circulation. 2021 Dec 14;144(24):1940-1954. doi: https://doi.org/10.1161/CIRCULATIONAHA.121.056414. Epub 2021 Nov 30.

  95. Deep learning enables genetic analysis of the human thoracic aorta. Pirruccello JP, Chaffin MD, Chou EL, Fleming SJ, Lin H, Nekoui M, Khurshid S, Friedman SF, Bick AG, et al. Nat Genet. 2022 Jan;54(1):40-51. doi: https://doi.org/10.1038/s41588-021-00962-4. Epub 2021 Nov 26.

  96. Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease. Katz DH, Tahir UA, Bick AG et al. Circulation. 2022 Feb;145(5):357-370. doi: https://doi.org/10.1161/CIRCULATIONAHA.121.055117. Epub 2021 Nov 24.

  97. Clonal Hematopoiesis Is Associated With Higher Risk of Stroke. Bhattacharya R, Zekavat SM, Haessler J, Fornage M, Raffield L, Uddin MM, Bick AG, et al. Stroke. 2022 Mar;53(3):788-797. doi: https://doi.org/10.1161/STROKEAHA.121.037388. Epub 2021 Nov 8.

  98. Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis. Kim PG, Niroula A, Shkolnik V, McConkey M, Lin AE, Słabicki M, Kemp JP, Bick A, et al. J Exp Med. 2021 Dec 6;218(12):e20211872. doi: https://doi.org/10.1084/jem.20211872. Epub 2021 Oct 26.

  99. Distinction of lymphoid and myeloid clonal hematopoiesis. Niroula A, Sekar A, Murakami MA, Trinder M, Agrawal M, Wong WJ, Bick AG, et al. Nat Med. 2021 Nov;27(11):1921-1927. doi: https://doi.org/10.1038/s41591-021-01521-4. Epub 2021 Oct 18.

  100. Expanding approaches to detect clonal hematopoiesis. Khan MAW, Bick AG. Haematologica. 2022 Aug 1;107(8):1739-1740. doi: https://doi.org/10.3324/haematol.2021.279818.

  101. ZBTB33 is mutated in clonal hematopoiesis and myelodysplastic syndromes and impacts RNA splicing. Beauchamp EM, Leventhal M, Bernard E, Hoppe ER … Bick AG, et al. Blood Cancer Discov. 2021 Sep;2(5):500-517. doi: https://doi.org/10.1158/2643-3230.BCD-20-0224. Epub 2021 Jul 14.

  102. Clonal Hematopoiesis of Indeterminate Potential: an Expanding Genetic Cause of Cardiovascular Disease. Bhattacharya R, Bick AG. Curr Atheroscler Rep. 2021 Sep 1;23(11):66. doi: https://doi.org/10.1007/s11883-021-00966-9.

  103. Generalizability of Polygenic Risk Scores for Breast Cancer Among Women With European, African, and Latinx Ancestry. Liu C, Zeinomar N, Chung WK, Kiryluk K … Bick AG, et al. JAMA Netw Open. 2021 Aug 2;4(8):e2119084. doi: https://doi.org/10.1001/jamanetworkopen.2021.19084.

  104. Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease. Marnell CS, Bick A, Natarajan P. J Mol Cell Cardiol. 2021 Dec;161:98-105. doi: https://doi.org/10.1016/j.yjmcc.2021.07.004. Epub 2021 Jul 21.

  105. Association of Diet Quality With Prevalence of Clonal Hematopoiesis and Adverse Cardiovascular Events. Bhattacharya R, Zekavat SM, Uddin MM, Pirruccello J, Niroula A, Gibson C, Griffin GK, Libby P, Ebert BL, Bick A, Natarajan P. JAMA Cardiol. 2021 Sep 1;6(9):1069-1077. doi: https://doi.org/10.1001/jamacardio.2021.1678.

  106. Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection. Zekavat, S.M., Lin, SH., Bick, A.G. et al. 2021 Jun. Nat Med. 27, 1012–1024. doi: https://doi.org/10.1038/s41591-021-01371-0.

  107. Clonal hematopoiesis associated with epigenetic aging and clinical outcomes. Daniel Nachun, Ake T. Lu, Alexander G. Bick, et al. 2021 May. Aging Cell. doi: https://doi.org/10.1111/acel.13366.

  108. Germline risk of clonal haematopoiesis. Silver, A.J., Bick, A.G. & Savona, M.R. 2021 Mar. Nat Rev Genet; doi: https://doi.org/10.1038/s41576-021-00356-6.

  109. Bidirectional Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of intermediate potential. Tetsushi Nakao, Alexander G. Bick, et al. 2021 Feb. medRxiv, 21252199; doi: https://doi.org/10.1101/2021.02.26.21252199.

  110. Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women. Michael C. Honigberg, Seyedeh M. Zekavat, Abhishek Niroula, Gabriel K. Griffin, Alexander G. Bick, et al. Circulation. 2020 Nov. 2021; 143: 410–423; doi: https://doi.org/10.1161/CIRCULATIONAHA.120.051775.

  111. Increased CHIP Prevalence Amongst People Living with HIV. Alexander G. Bick, Konstantin Popadin, et al. 2020 Nov. medRxiv, 20225607; doi: https://doi.org/10.1101/2020.11.06.20225607.

  112. Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Bick, A.G., Weinstock, J.S., Nandakumar, S.K. et al. Nature. 2020 Jul. 586, 763–768; doi: https://doi.org/10.1038/s41586-020-2819-2.

  113. Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis. Alexander G. Bick, James P. Pirruccello, et al. 2020 Nov. Circulation. 141: 124–131; doi: https://doi.org/10.1161/CIRCULATIONAHA.119.044362.

  114. Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer. Seyedeh M. Zekavat, Shu-Hong Lin, Alexander G. Bick, et al. 2020 Nov. medRxiv, 20230821; doi: https://doi.org/10.1101/2020.11.12.20230821.

  115. Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells. Erik L. Bao, Satish K. Nandakumar, Xiaotian Liao, Alexander G. Bick, et al. Nature. 2020 Oct. 586, 769–775; doi: https://doi.org/10.1038/s41586-020-2786-7.

  116. Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions. Akl C. Fahed, Minxian Wang, Julian R. Homburger, Aniruddh P. Patel, Alexander G. Bick, et al. Nat Commun. 2020 Aug. 11, 3635; doi: https://doi.org/10.1038/s41467-020-17374-3.

  117. Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy. Pirruccello, J.P., Bick, A., Wang, M. et al. Nat Commun. 2020 Jul. 11, 2254; doi: https://doi.org/10.1038/s41467-020-15823-7.

  118. Proteomic Profiling in Biracial Cohorts Implicates DC-SIGN as a Mediator of Genetic Risk in COVID-19. Daniel H. Katz, Usman A. Tahir, Debby Ngo, Mark Benson, Alexander G. Bick, et al. 2020 June. medRxiv, 20125690; doi: https://doi.org/10.1101/2020.06.09.20125690.

  119. Parenting While in Training: A Comprehensive Needs Assessment of Residents and Fellows. Kirti Magudia, Thomas S. C. Ng, Alexander G. Bick, et al. J Grad Med Educ. 2020 Apr. 12 (2): 162–167; doi: https://doi.org/10.4300/JGME-D-19-00563.1.

  120. Titin Truncating Variants in Adults Without Known Congestive Heart Failure. James P. Pirruccello, Alexander Bick, et al. J Am Coll Cardiol. 2020 Mar. 75 (10) 1239–1241; doi: https://doi.org/10.1016/j.jacc.2020.01.013.

  121. Analysis of cardiac magnetic resonance imaging traits in 29,000 individuals reveals shared genetic basis with dilated cardiomyopathy. James P. Pirruccello, Alexander Bick, et al. 2020 Feb. bioRxiv, 946038; doi: https://doi.org/10.1101/2020.02.12.946038.

  122. Association of APOL1 Risk Alleles With Cardiovascular Disease in Blacks in the Million Veteran Program. Alexander G. Bick, Elvis Akwo, et al. 2019 Aug. 140: 1031–1040; doi: https://doi.org/10.1161/CIRCULATIONAHA.118.036589.

  123. Prevalence and clinical importance of titin truncating variants in adults without known congestive heart failure. James P. Pirruccello, Alexander Bick, et al. 2019 Aug. medRxiv 19005058; doi: https://doi.org/10.1101/19005058.

  124. Clonal Hematopoiesis of Indeterminate Potential Reshapes Age-Related CVD: JACC Review Topic of the Week. Sumeet A. Khetarpal, Arman Qamar, Alexander G. Bick, et al. J Am Coll Cardiol. 2019 Jul. 74 (4) 578–586; doi: https://doi.org/10.1016/j.jacc.2019.05.045.